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120,122,125,133,134 In addition, insulin signaling is important for synaptic plasticity

These medications imitate the GLP-1 hormone, which signals the body to secrete insulin, and make it easier for the patients blood sugar levels to be controlled

Both protocols require consistent use

Participants received diet (500 kcal deficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0 mg, n =9095), placebo ( n =98) or open-label orlistat (120 mg 3, n =95)

Diabetologia 53 (3), 552561